Hexapeptide-9 — Collagen-Stimulating Peptide

Hexapeptide-9 — 1000ppm solution

Hexapeptide-9 is a targeted collagen-stimulating peptide that works at the dermal matrix level — signalling fibroblasts to upregulate collagen synthesis and improve the structural integrity of ageing or compromised skin. First introduced to cosmetic science in 2010, it represents a more sophisticated second generation of collagen-stimulating peptides, working through a distinct signalling pathway from the well-known Matrixyl family and delivering complementary rather than redundant activity when the two are combined in the same formula.

The mechanism is precise: Hexapeptide-9 binds to receptors on dermal fibroblasts and triggers the production of both Type I and Type III collagen — the two primary structural collagens responsible for skin firmness, thickness and resistance to mechanical stress. As collagen levels decline with age, the skin loses its ability to spring back, fine lines deepen into wrinkles, and the overall architecture of the face begins to deflate. Hexapeptide-9 addresses this by restoring the biological signal that fibroblasts need to keep producing collagen.

Supplied pre-diluted at 1000ppm in a water and glycerin base — a notably high concentration for this peptide — and ready to blend straight into your formulation.

How to use

• Use level: 3–7% of your total formula. This refers to the solution as supplied.
• Add to the water phase at cool-down, once your mixture is below 40°C.
• Formulate at pH 4.5–7.5.
• Water-soluble — no special solubilisation required.
• Do not apply neat to the skin — this is a formulation additive. Always blend into a serum, gel or cream and patch test the finished formula.

Specification

• INCI: Water, Glycerin, Hexapeptide-9
• Active concentration: 1000ppm (0.1%) Hexapeptide-9
• Appearance: Clear liquid
• Solubility: Water-soluble
• pH range (final formula): 4.5–7.5
• Maximum temperature: Add below 40°C
• Storage: Refrigerate for long-term storage. Avoid heat, humidity and direct sunlight.
• Shelf life: At least 24 months

Formulating with it

Hexapeptide-9 is a clean active with no colour, no significant odour and no impact on product texture. It pairs particularly well with Palmitoyl Pentapeptide-4 (Matrixyl) and Palmitoyl Tripeptide-1 for a multi-pathway collagen approach, and with Copper Tripeptide-1 (GHK-Cu) for formulators combining collagen stimulation with regenerative activity in the same product.

Particularly well suited to firming serums, neck and décolletage treatments, eye creams, and any product targeting loss of elasticity and structural volume in mature skin.

Supplied as a cosmetic raw ingredient for external use in formulation only. Product information is provided for general reference and does not constitute medical or therapeutic advice. Customers are responsible for ensuring the ingredient is suitable for their intended use and compliant with relevant cosmetic regulations.

Technical data sheet and batch Certificate of Analysis available on request — email info@thesourcery.co.nz