SNAP‑8 Peptide (SNAP 8)

SNAP-8 (Acetyl Octapeptide-3) — 500ppm ready-to-use solution

SNAP-8 is an eight-amino-acid peptide developed as a successor to Argireline, and one of the most widely used expression-line actives in modern skincare. It works on the SNAP-25 protein involved in neuromuscular signalling, softening the appearance of dynamic lines — forehead lines, crow's feet and the lines around the mouth — rather than acting on skin structure.

It is supplied here pre-diluted at 500ppm active, ready to be blended straight into your formulation.

How to use

• Use level: 3–10% of your total formula. This refers to the solution as supplied, not the pure peptide. 10% is the upper end of the useful range — going higher simply dilutes your other actives.
• Add to the water phase at cool-down, once your mixture is below 40°C. The peptide is heat-sensitive.
• Formulate at pH 5.0–7.0.
• Do not apply neat to the skin. This is a formulation additive, not a finished product — always blend it into a serum, gel or cream, and patch test any new formula before regular use.

Pairs well with

Argireline (Acetyl Hexapeptide-8) and Syn-Ake equivalent, both of which work on related but distinct pathways. Also works well alongside hyaluronic acid, panthenol and the Matrixyl-family collagen peptides in a single serum.

Specification

• INCI: Water, Glycerin, Acetyl Octapeptide-3
• Active concentration: 500ppm (0.05%) Acetyl Octapeptide-3
• Appearance: Clear, colourless liquid
• Solubility: Water-soluble
• pH range (final formula): 5.0–7.0
• Maximum temperature: Add below 40°C
• Storage: Keep sealed, cool and out of direct light. Refrigeration is ideal. Dark packaging recommended for finished products.

Published data

Studies on acetyl octapeptide-3 solutions at 10% use level, applied twice daily for 28 days, reported reductions in the depth of eye-area wrinkles measured by confocal profilometry. Acetyl octapeptide-3 is generally reported as more active than its predecessor acetyl hexapeptide-8 at equivalent use levels. Published data relates to the peptide generally; results in any finished formula depend on the full formulation and on individual skin.

Supplied as a cosmetic raw ingredient for external use in formulation only. Product information is provided for general reference and does not constitute medical or therapeutic advice. Customers are responsible for ensuring the ingredient is suitable for their intended use and compliant with relevant cosmetic regulations.

Technical data sheet and batch Certificate of Analysis available on request — email info@thesourcery.co.nz